Endocochlear potential and action potential.
نویسندگان
چکیده
منابع مشابه
K+ cycling and the endocochlear potential.
Sensory transduction in the cochlea and the vestibular labyrinth depends on the cycling of K+. In the cochlea, endolymphatic K+ flows into the sensory hair cells via the apical transduction channel and is released from the hair cells into perilymph via basolateral K+ channels including KCNQ4. K+ may be taken up by fibrocytes in the spiral ligament and transported from cell to cell via gap junct...
متن کاملStria vascularis as source of endocochlear potential.
IT IS WELL KNOWN (1, 2, 12, 6) that, when a recording microelectrode is pushed into the endolympatic space of the cochlea of a guinea pig or a cat, the potential at the tip of the electrode rises 70-90 mV. above the potential level in the perilymphatic space. Although the ionic composition of the endolymph is unique among various body fluids because of its high potassium content (lo), the DC po...
متن کاملThe endocochlear potential alters cochlear micromechanics.
Acoustic stimulation gates mechanically sensitive ion channels in cochlear sensory hair cells. Even in the absence of sound, a fraction of these channels remains open, forming a conductance between hair cells and the adjacent fluid space, scala media. Restoring the lost endogenous polarization of scala media in an in vitro preparation of the whole cochlea depolarizes the hair cell soma. Using b...
متن کاملSupporting sensory transduction: cochlear fluid homeostasis and the endocochlear potential.
The exquisite sensitivity of the cochlea, which mediates the transduction of sound waves into nerve impulses, depends on the endocochlear potential and requires a highly specialized environment that enables and sustains sensory function. Disturbance of cochlear homeostasis is the cause of many forms of hearing loss including the most frequently occurring syndromic and non-syndromic forms of her...
متن کاملKCNJ10 (Kir4.1) potassium channel knockout abolishes endocochlear potential.
Stria vascularis of the cochlea generates the endocochlear potential and secretes K(+). K(+) is the main charge carrier and the endocochlear potential the main driving force for the sensory transduction that leads to hearing. Stria vascularis consists of two barriers, marginal cells that secrete potassium and basal cells that are coupled via gap junctions to intermediate cells. Mice lacking the...
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ژورنال
عنوان ژورنال: Practica Oto-Rhino-Laryngologica
سال: 1985
ISSN: 1884-4545,0032-6313
DOI: 10.5631/jibirin.78.1471